Influence of androgen deprivation therapy on the severity of COVID-19 in prostate cancer patients.

BACKGROUND: The TMPRSS2 protein has been involved in severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2). The production is regulated by the androgen receptor (AR). It is speculated that androgen deprivation therapy (ADT) may protect patients affected by prostate cancer (PC) from SARS-CoV-2 infection. METHODS: This is a retrospective study of patients treated for COVID-19 in our institution who had a previous diagnosis of PC. We analyzed the influence of exposure of ADT on the presence of severe course of COVID-19. RESULTS: A total of 2280 patients were treated in our center for COVID-19 with a worse course of disease in males (higher rates of hospitalization, intense care unit [ICU] admission, and death). Out of 1349 subjects registered in our PC database, 156 were on ADT and 1193 were not. Out of those, 61 (4.52%) PC patients suffered from COVID-19, 11 (18.0%) belonged to the ADT group, and 50 (82.0%) to the non-ADT group. Regarding the influence of ADT on the course of the disease, statistically significant differences were found neither in the death rate (27.3% vs. 34%; p = 0.481), nor in the presence of severe COVID-19: need for intubation or ICU admission (0% vs. 6.3%; p = 0.561) and need for corticoid treatment, interferon beta, or tocilizumab (60% vs. 34.7%; p = 0.128). Multivariate analysis adjusted for clinically relevant comorbidities did not find that ADT was a protective factor for worse clinical evolution (risk ratio [RR] 1.08; 95% confidence interval [CI], 0.64-1.83; p = 0.77) or death (RR, 0.67; 95% CI, 0.26-1.74; p = 0.41). CONCLUSIONS: Our study confirms that COVID-19 is more severe in men. However, the use of ADT in patients with PC was not shown to prevent the risk of severe COVID-19.

Infecciones del tracto urinario de origen hospitalario en pacientes portadores de catéter urinario: factores de riesgo, características microbiológicas y resistencias a antibióticos / Healthcare-associated urinary tract infections in patients with a urinary catheter: Risk factors, microbiological characteristics and patterns of antibiotic resistance

OBJETIVO: Las infecciones del tracto urinario asociadas a catéteres urinarios (ITU-AC) son la causa más frecuente de infección nosocomial, presentando altas tasas de resistencias. Están asociadas a complicaciones potencialmente severas, implicando mayor coste económico. Nuestro objetivo fue analizar las características de las ITU nosocomiales asociadas a catéter urinario en un Servicio de Urología. MÉTODOS: Llevamos a cabo un estudio prospectivo desde Noviembre de 2011 hasta Octubre de 2013, evaluando la incidencia de infecciones nosocomiales asociadas a los catéter de derivación urinaria en una planta de hospitalización urológica. Además evaluamos los factores de riesgo como comorbilidades, sondaje previo al ingreso y cirugía durante la hospitalización. Se presentan los patrones microbiológicos y tasas de resistencia de los gérmenes aislados. RESULTADOS: La incidencia de ITU-AC nosocomial fue de 8,2% (189/2283 pacientes portadores d e catéteres urinarios). La edad media fue de 67,4 ± 14,26 años, el 90,2% fueron sometidos a un procedimiento quirúrgico (p< 0,001), 14,8% tenían litiasis urinaria (p = 0,058) y el 46% portaban cateterismo urinario previo al ingreso (p < 0,001). Los microorganismos más frecuentemente aislados fueron Escherichia coli (22,6%), Enterococcus (21,9%) y Pseudomonas aeruginosa (13,9%). E.coli mostró una resistencia de 41,9% para quinolonas y un 33,3% fueron productores de β-lactamasas de espectro extendido (ESBL). P.aeruginosa presentaba 42,1% de resistencias a quinolonas y hasta un 21,1% a carbapenems. CONCLUSIONES: Portar un catéter urinario previo al ingreso y la realización de un procedimiento quirúrgico urológico durante el ingreso son factores de riesgo de ITU nosocomial en pacientes ingresados en el Servicio de Urología. Existe una elevada incidencia de gérmenes resistentes y de patógenos no clásicos como Enterococcus spp

OBJECTIVE: Catheter-associated urinary tract infections (CAUTIs) are the most common nosocomial acquired infections, with high resistance rates. CAUTIs are a potentially severe complication in hospitalized patients and imply higher costs. Our aim was to analyze the characteristics of CAUTIs in our Urology department. METHODS: Between November 2011 and October 2013, a prospective observational study was carried out analyzing the incidence of healthcare-associated urinary tract infections in patients admitted to the urology ward with an indwelling urinary catheter. Furthermore, we evaluated associated risks factors and comorbidities such as urinary catheter at the time of admission or urological surgery during the hospitalization. We also presented our results regarding the microbiological characteristics and patterns of resistance to antibiotics in patients with CAUTI admitted in our service. RESULTS: The incidence of CAUTI was 8.2% (189/2283 patients who had urinary catheter). Mean age was 67.4 ± 14.26 years, 90.2% underwent a surgical procedure (p < 0.001), 14.8% had a urinary stone (p = 0.058) and 46% had a urinary catheter before admission (p < 0.001). The most commonly isolated pathogens were Escherichia coli (22.6%), Enterococcus (21.9%) and Pseudomonas aeruginosa (13.9%). E.coli showed resistance rates of 41.9% for quinolones, 33.3% of them produced extended spectrum βeta-lactamase (ESBL). P.aeruginosa showed resistance rates of 42.1% for quinolones and 21.1% for carbapenems. CONCLUSIONS: Healthcare-associated CAUTI in patients hospitalized in a urology ward are related to risks factors such as having a urinary catheter before admission and undergoing a surgical procedure. Moreover, CAUTIs have higher incidence of pathogens with antibiotic resistances and non-common pathogens such as Enterococcus spp

[Healthcare-associated urinary tract infections in patients with a urinary catheter: Risk factors, microbiological characteristics and patterns of antibiotic resistance]. / INFECCIONES DEL TRACTO URINARIO DE ORIGEN HOSPITALARIO EN PACIENTES PORTADORES DE CATÉTER URINARIO: FACTORES DE RIESGO, CARACTERÍSTICAS MICROBIOLÓGICAS Y RESISTENCIAS A ANTIBIÓTICOS.

OBJECTIVE: Catheter-associated urinary tract infections (CAUTIs) are the most common nosocomial acquired infections, with high resistance rates. CAUTIs are a potentially severe complication in hospitalized patients and imply higher costs. Our aim was to analyze the characteristics of CAUTIs in our Urology department. METHODS: Between November 2011 and October 2013, a prospective observational study was carried out analyzing the incidence of healthcare-associated urinary tract infections in patients admitted to the urology ward with an indwelling urinary catheter. Furthermore, we evaluated associated risks factors and comorbidities such as urinary catheter at the time of admission or urological surgery during the hospitalization. We also presented our results regarding the microbiological characteristics and patterns of resistance to antibiotics in patients with CAUTI admitted in our service. RESULTS: The incidence of CAUTI was 8.2% (189/2283 patients who had urinary catheter). Mean age was 67.4±14.26 years, 90.2% underwent a surgical procedure (p<0.001), 14.8% had a urinary stone (p=0.058) and 46% had a urinary catheter before admission (p<0.001). The most commonly isolated pathogens were Escherichia coli (22.6%), Enterococcus (21.9%) and Pseudomonas aeruginosa (13.9%). E.coli showed resistance rates of 41.9% for quinolones, 33.3% of them produced extended spectrum Β-lactamase (ESBL). P.aeruginosa showed resistance rates of 42.1% for quinolones and 21.1% for carbapenems. CONCLUSIONS: Healthcare-associated CAUTI in patients hospitalized in a urology ward are related to risks factors such as having a urinary catheter before admission and undergoing a surgical procedure. Moreover, CAUTIs have higher incidence of pathogens with antibiotic resistances and non-common pathogens such as Enterococcus spp.

Survey of satisfaction in hospitalized patients at a urology department.

OBJECTIVES: To assess the level of satisfaction with the care provided to hospitalized patients in the Department of Urology at 12 de Octubre Hospital and analyze demographic and clinical factors influencing satisfaction. METHODS: A cross-sectional study was carried out using the SERVQHOS questionnaire, delivered at the time of discharge. A data sheet for each patient was collected, which included if they undergone surgery, type of surgery and whether or not presented postoperative complications, rated by the Clavien scale. RESULTS: 479 surveys were collected, with a participation of 92%. 95.4% of patients rated their overall level of satisfaction with the care received as "satisfied" or "very satisfied". Top-rated aspects were the kindness of the staff and personalized attention. The worst rated issue was the condition of the rooms, but this did not influence perceived quality. Variables related to greater overall satisfaction were male gender, shorter hospital stay, knowing the name of the nurse, the information received and subjective factors such as personalized service and willingness to help. CONCLUSIONS: Our patients show a high level of satisfaction, which is mainly dependent on subjective factors. The negative issues related to the facilities do not mean lower satisfaction.

Estudio de satisfacción en pacientes hospitalizados en un Servicio de Urología / Survey of satisfaction in hospitalized patients at a Urology Department

OBJETIVO: Evaluar el grado de satisfacción con la atención prestada de los pacientes hospitalizados en el servicio de Urología del Hospital 12 de Octubre y analizar los factores sociodemográficos y clínicos que influyen en el grado de satisfacción. MÉTODOS: Estudio transversal utilizando el cuestionario SERVQHOS, entregado en el momento del alta. Se recogió una hoja de datos de cada paciente que incluía si se había sometido a intervención quirúrgica, el tipo de cirugía y si había presentado complicaciones postquirúrgicas valoradas mediante la escala Clavien. RESULTADOS: Se recogieron 479 encuestas, con una participación del 92%. El 95,4% de los pacientes calificaban su nivel de satisfacción global con los cuidados recibidos como satisfechos o muy satisfechos. Los aspectos mejor calificados fueron la amabilidad del personal y el trato personalizado. Destaca como aspecto peor valorado el estado de las habitaciones, aunque no influye en la calidad percibida. Las variables relacionadas con una mayor satisfacción global fueron el sexo masculino, menor estancia hospitalaria, conocer el nombre de la enfermera, la información recibida y factores subjetivos como el trato personalizado y la disposición a ayudar. CONCLUSIONES: Nuestros pacientes presentan unos índices de satisfacción elevados, que se relacionan sobre todo con los factores subjetivos. Los aspectos negativos relacionados con las instalaciones no suponen un menor grado de satisfacción (AU)

OBJECTIVES: To assess the level of satisfaction with the care provided to hospitalized patients in the Department of Urology at 12 de Octubre Hospital and analyze demographic and clinical factors influencing satisfaction. METHODS: A cross-sectional study was carried out using the SERVQHOS questionnaire, delivered at the time of discharge. A data sheet for each patient was collected, which included if they undergone surgery, type of surgery and whether or not presented postoperative complications, rated by the Clavien scale. RESULTS: 479 surveys were collected, with a participation of 92%. 95.4% of patients rated their overall level of satisfaction with the care received as "satisfied" or "very satisfied". Top-rated aspects were the kindness of the staff and personalized attention. The worst rated issue was the condition of the rooms, but this did not influence perceived quality. Variables related to greater overall satisfaction were male gender, shorter hospital stay, knowing the name of the nurse, the information received and subjective factors such as personalized service and willingness to help. CONCLUSIONS: Our patients show a high level of satisfaction, which is mainly dependent on subjective factors. The negative issues related to the facilities do not mean lower satisfaction (AU)

Evaluation of current errors within the administration of phosphodiesterase-5 inhibitors after more than 10 years of use.

OBJECTIVE: To detect current errors within the administration of phosphodiesterase type 5 inhibitors (PDE5is) and evaluate and elucidate what percentage of patients could be recovered for oral therapy with different subtypes of PDE5is through a re-education program. METHODS: Two hundred fifty patients remitted to the andrology unit were prospectively analyzed. Patients' chief complaint was erectile dysfunction despite treatment with PDE5i. The International Index of Erectile Function was used to measure erectile function. A structured interview was developed to evaluate the most frequent errors within the administration of PDE5is. A re-education program was offered to patients with incomplete or incorrect use of PDE5is according to the structured interview, classifying them into true nonresponders or false nonresponders. Finally, the percentage of patients who could be recovered for oral therapy with other PDE5is was analyzed. RESULTS: A total of 172 patients (69%) presented some error within drug administration. The most common error was not trying >1 PDE5i (41%). A re-education program was offered to these nonresponders, and 115 (66.9%) accepted. Up to 27 (23.5%) did not respond to the re-education program and were classified as true nonresponders, whereas 88 (76.5%) had a positive response to treatment and were thus included in the false nonresponder group. CONCLUSION: Two-thirds of patients remitted to our andrology unit and cataloged as nonresponders were in fact using PDE5i in suboptimal conditions. Offering patients more accurate information provided almost 76% with good results using PDE5is and could therefore be successfully treated with these drugs.

Healthcare-associated infections in a department of urology: incidence and patterns of antibiotic resistance.

OBJECTIVE: Healthcare-associated infections (HAIs) constitute a potentially severe complication which implies higher costs. A full knowledge of their microbiological characteristics and risk factors is of paramount importance for adequate management. The purpose of this study was to carry out an analysis of HAIs in patients admitted to a department of urology. MATERIAL AND METHODS: Between November 2011 and October 2012, a prospective observational study was carried out analysing HAIs in patients admitted to the urology department of a tertiary care university hospital in Spain, reviewing the incidence and types of HAIs, the microorganisms isolated and patterns of resistance to antibiotics. Risk factors for HAIs were also evaluated. RESULTS: HAIs were seen in 110 (6.5%) out of 1701 patients. Hypertension, a higher American Society of Anesthesiologists (ASA) score and surgery showed a statistical association with a higher risk of HAIs, and patients who underwent radical cystectomy had a high incidence of HAIs (10 out of 14). The most common HAIs were urinary tract infections (66.1%), followed by surgical site infections (16.5%), intra-abdominal abscesses (10.4%) and venous catheter-associated bacteraemia (6.1%). The most frequently isolated microorganisms were Escherichia coli (31.8%), then Enterococcus (17.6%) and Pseudomonas (12.9%). Escherichia coli showed resistance rates of 48.1% for ampicillin/amoxicillin plus ß-lactamase inhibitor, 51.9% for fluoroquinolones, and 33.3% were extended-spectrum ß-lactamase-producing E. coli. Pseudomonas aeruginosa showed a resistance rate of 36.4% for fluoroquinolones and carbapenems. CONCLUSIONS: HAIs usually occur in patients with risk factors. Radical cystectomy is associated with a high incidence of HAIs. Microorganisms associated with HAIs show high rates of resistance, which must be taken into account when selecting appropriate antibiotic therapy.

Paciente con SDT y síntomas del tracto urinario inferior (STUI) / Patient with TDS and lower urinary tract symptoms (LUTS)

OBJETIVO: Nuevas investigaciones hacen incapié en la interrelación existente entre la hiperplasia benigna de próstata, los síntomas del tracto urinario inferior, la disfunción eréctil y el déficit de testosterona; ejerciendo éste último un papel de coactivador en todas ellas. Planteamos en este artículo un paciente tipo, que consulta por clínica atribuible a HBP, para tratar al paciente globalmente en términos de calidad miccional, esfera sexual y DT. MÉTODO/RESULTADOS: Varón de 61 años, obeso, hipertenso e hipercolesterolémico, que consulta por cuadro miccional mixto de años de evolución con IPSS de 12 e IIEF-5 de 22. TR: II/IV, adenomatosa. En la analítica se observa: PSA 1,9 ng/dl, testosterona total 238 ng/dl, triglicéridos 213 mg/dl, glucosa 89 mg/dl. Flujometría: volumen de 256 ml, flujo máximo de 12 ml/s, medio de 5,7 ml/s y residuo postmiccional de 15ml. Ecografía de aparato urinario: detrusor de 5 mm y volumen prostático de 39 cc. Hoy en día se considera que el origen de los STUI en el hombre es multi-etiológico, habiendo quien incluye el déficit de testosterona como una causa de los mismos. Atendiendo a los criterios clásicos, parece un buen candidato para terapia combinada mediante un alfa-bloqueante y un inhibidor de la 5 alfa reductasa; si bien otra opción terapéutica sería el recientemente aprobado como tratamiento para STUI en el varón: tadalafilo 5 mg al día. La administración de testosterona en el varón afecto de STUI es un tema de debate controvertido. Trataría el déficit del paciente, con el beneficio que conlleva a nivel metabólico, e implicaría adicionalmente un ambiente óptimo para la administración de inhibidores de la 5-PDE.Además, a juzgar por algunas de las evidencias actuales, podría ayudar a la mejoría de los STUI del paciente (AU)

CONCLUSIONES: El tratamiento sustitutivo con testosterona, a falta de estudios más robustos, no parece interferir negativamente en la evolución de la HBP pudiendo incluso mejorar los síntomas miccionales en caso de constatarse déficit androgénico (AU)

OBJETIVE: New investigations focus on the relationship between benign prostatic hyperplasia, lower urinary tract symptoms, erectile dysfunction and testosterone deficit; giving to this last one a common role in all of them. In this paper, we present a typical patient who complains of symptoms related to BPH, to treat him in terms of micturition quality, sexual function and hypogonadism. METHODS/RESULTS: 61 year-old male, with obesity, hypertension and hypercholesterolemia, who complains of long term mixed urinary symptoms, with an IPSS of 12 and IIEF-5 of 22. DRE: II/IVprostate, adenomatous. Blood parameters: PSA 1.9 ng/dl, total testosterone 238 ng/dl, triglycerides 213 mg/dl, glucose 89 mg/dl. Uroflowmetry: total volume 256 ml, maximum flow 12 ml/s, average 5.7 ml/s and post-void volume of 15 ml. Urinary ultra- sound: 5 mm detrusor and prostate volume of 39 cm3. Nowadays, LUTS are considered multietiologic, including testosterone as one of the causes. According to the classic criteria, this patient fits for treatment with combination therapy, as well as for daily PDE5i, recently approved for LUTS therapy. Administration of testosterone to treat LUTS is still controversial. It could restore the patient’s levels of testosterone, improving the metabolic syndrome and creating an optimal environment for the 5PDEi. Nevertheless, according to some current scientific evidences, it could help improving LUTS. CONCLUSIONS: Given the necessity of larger studies, testosterone supplementation therapy seems to not worsen the evolution of BHP. It could even improve them if the testosterone deficit is documented (AU)

Ischemic Gangrene of the Glans following Penile Prosthesis Implantation.

The development of ischemic gangrene of the penis following implantation of prosthesis is unusual, and very few cases are available in the literature. As a result, no established treatment protocol is available. We report our experience within a case of gangrene of the glans following implantation of a three-component prosthesis. We present a 53-year-old male, smoker with diabetes and hypercholesterolemia, who underwent surgery for the insertion of a penile prosthesis with 3 components to correct his erectile dysfunction and severe Peyronie's disease. The procedure was carried out without incidents. During the postoperative period, the patient began to complain from penile and perineal pain. He developed avascular necrosis of the glans. The necrosed area was excised. Four weeks later, he developed fever and perineal pain arriving to the emergency room with the prosthesis extruding through the glans. He had emergency surgery to remove the prosthesis plus surgical lavage and was prescribed broad-spectrum antibiotic therapy. Four weeks later, the penis was completely revascularized and reepithelialized. Ischemic gangrene following penile prosthesis implantation takes place in patients with poor peripheral vascularisation. Diabetes mellitus has been the common denominator to all of the reported cases.